LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation

The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for remaining apoptotic debris in regulating the immunologic response to and growth...

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Главные авторы:	Jamie A. Moore, Jayna J. Mistry, Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 2022-03-01
Серии:	The Journal of Clinical Investigation
Предметы:	Hematology Oncology
Online-ссылка:	https://doi.org/10.1172/JCI153157
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