LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation

The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for remaining apoptotic debris in regulating the immunologic response to and growth...

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Detalhes bibliográficos

Principais autores:	Jamie A. Moore, Jayna J. Mistry, Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2022-03-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Hematology Oncology
Acesso em linha:	https://doi.org/10.1172/JCI153157
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