Emerging significance of E3 ubiquitin ligases and Deubiquitinases in pulmonary hypertension

Abstract Pulmonary hypertension (PH) is a progressive, life-threatening cardiovascular disorder. It features irreversible pulmonary vascular remodeling and causes right ventricular failure and mortality. The underlying pathogenesis of PH is incompletely elucidated. Ubiquitination is a reversible pos...

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Hlavní autoři:	Chao-Wei Ding, Jia-Yong Qiu, Hui Shen, Yi Yan, Ze-Xin Liu, Shen-Shen Huang, Yue-Jiao Ma, Zhi-Cheng Jing
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	Molecular Medicine
Témata:	Pulmonary hypertension Ubiquitin ligase Ubiquitination Deubiquitination Therapeutic targets
On-line přístup:	https://doi.org/10.1186/s10020-026-01478-5
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