CXCR4 has a dual role in improving the efficacy of BCMA-redirected CAR-NK cells in multiple myeloma

Multiple myeloma (MM) is a plasma cell disease with a preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant milieu in solid cancers, but also to BM-resident AML...

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Үндсэн зохиолчид:	Michael W. Moles, Henry Erdlei, Lutz Menzel, Marialucia Massaro, Agnese Fiori, Mario Bunse, Moritz Schrimpf, Kerstin Gerlach, Venugopal Gudipati, John Reiser, Ketan Mathavan, Jodie P. Goodrich, Johannes B. Huppa, Jan Krönke, Bahram Valamehr, Uta E. Höpken, Armin Rehm
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2024-06-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	BCMA chimeric antigen receptor NK cells multiple myeloma chemokine receptor CXCR4 adoptive T cell therapy
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383136/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!