CXCR4 has a dual role in improving the efficacy of BCMA-redirected CAR-NK cells in multiple myeloma

Multiple myeloma (MM) is a plasma cell disease with a preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant milieu in solid cancers, but also to BM-resident AML...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Michael W. Moles, Henry Erdlei, Lutz Menzel, Marialucia Massaro, Agnese Fiori, Mario Bunse, Moritz Schrimpf, Kerstin Gerlach, Venugopal Gudipati, John Reiser, Ketan Mathavan, Jodie P. Goodrich, Johannes B. Huppa, Jan Krönke, Bahram Valamehr, Uta E. Höpken, Armin Rehm
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-06-01
Edice:	Frontiers in Immunology
Témata:	BCMA chimeric antigen receptor NK cells multiple myeloma chemokine receptor CXCR4 adoptive T cell therapy
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383136/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!