Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritan...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ijeoma F. Uchegbu, Jan Breznikar, Alessandra Zaffalon, Uche Odunze, Andreas G. Schätzlein
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-05-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	cyclosporine A Molecular Envelope Technology (MET) N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) eye penetration enhancer
Online-Zugang:	https://www.mdpi.com/1999-4923/13/5/744
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