Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritan...

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Hlavní autoři:	Ijeoma F. Uchegbu, Jan Breznikar, Alessandra Zaffalon, Uche Odunze, Andreas G. Schätzlein
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-05-01
Edice:	Pharmaceutics
Témata:	cyclosporine A Molecular Envelope Technology (MET) N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) eye penetration enhancer
On-line přístup:	https://www.mdpi.com/1999-4923/13/5/744
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