A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma

Abstract Cancers evolve not only through the acquisition and clonal transmission of somatic mutations but also by epigenetic mechanisms that modify cell phenotype. Here, we use histology-guided and spatial transcriptomics to characterize hepatoblastoma, a childhood liver cancer that exhibits signifi...

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Detalhes bibliográficos

Principais autores:	Peng V. Wu, Matt Fish, Florette K. Hazard, Chunfang Zhu, Sujay Vennam, Hannah Walton, Dhananjay Wagh, John Coller, Joanna Przybyl, Maurizio Morri, Norma Neff, Robert B. West, Roel Nusse
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-53802-4
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