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Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

Abstract Background Increasing evidence implicates dysfunctional proteostasis and the involvement of the autophagic and endo-lysosomal system and the ubiquitin-proteasome system in neurodegenerative diseases. In Alzheimer’s disease (AD), there is an accumulation of autophagic vacuoles within the neu...

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Principais autores: Simon Sjödin, Gunnar Brinkmalm, Annika Öhrfelt, Lucilla Parnetti, Silvia Paciotti, Oskar Hansson, John Hardy, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
coleção:Alzheimer’s Research & Therapy
Assuntos:
Alzheimer’s disease
Biomarker
CSF
Mass spectrometry
Parkinson’s disease
Acesso em linha:http://link.springer.com/article/10.1186/s13195-019-0533-9
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