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Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model

Abstract Sensorineural hearing loss (SNHL) is characterized by cochlear inflammation, macrophage activation, and degeneration of hair cells, synapses, and neurons. Macrophage-mediated inflammation in the damaged cochlea is regulated via CX3CR1-CX3CL1 signaling, where the fractalkine ligand CX3CL1 se...

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Principais autores: Dinesh Y. Gawande, Sree Varshini Murali, Shriti S. Thakur, Savlatjon Rahmatulloev, Emma J. Nicolaisen, Lyudmila Batalkina, Astrid E. Cardona, Tejbeer Kaur
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-08-01
Serier:Journal of Neuroinflammation
Fag:
Macrophage
Fractalkine
CX3CR1
Polymorphism
Hearing loss
Noise trauma
Online adgang:https://doi.org/10.1186/s12974-025-03524-1
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