Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration

Background: Parkinson’s disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation. The molecular link on how neuroinflammation upregulates neur...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Lucia Yi-Ru Chung, Yi-Ting Lin, Chi Liu, Yi-Cheng Tai, Han-Yi Lin, Chin-Hsien Lin, Ching-Chow Chen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2022-03-01
Σειρά:	Frontiers in Pharmacology
Θέματα:	microglia–neuron coculture neuroinflammation Toll-like receptors autophagic flux synucleinopathy neurodegeneration
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fphar.2022.845930/full
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