Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

Intraflagellar transport (IFT) is a fundamental process driving ciliogenesis in most eukaryotic organisms. IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation, and several disease-causing IFT172 variants have been identified in ciliopathy patients. While IFT172 i...

Description complète

Détails bibliographiques

Auteurs principaux:	Nevin K Zacharia, Stefanie Kuhns, Niels Boegholm, Anni Christensen, Jiaolong Wang, Narcis A Petriman, Anna Lorentzen, Jindriska L Fialova, Lucie Menguy, Sophie Saunier, Søren Tvorup Christensen, Jens S Andersen, Sagar Bhogaraju, Esben Lorentzen
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2026-06-01
Collection:	eLife
Sujets:	cilia intraflagellar transport protein structure ciliopathy IFT172 U-box domain
Accès en ligne:	https://elifesciences.org/articles/104906
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!