Insights gained from a comprehensive all-against-all transcription factor binding motif benchmarking study

Abstract Background Positional weight matrix (PWM) is a de facto standard model to describe transcription factor (TF) DNA binding specificities. PWMs inferred from in vivo or in vitro data are stored in many databases and used in a plethora of biological applications. This calls for comprehensive be...

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Autori principali:	Giovanna Ambrosini, Ilya Vorontsov, Dmitry Penzar, Romain Groux, Oriol Fornes, Daria D. Nikolaeva, Benoit Ballester, Jan Grau, Ivo Grosse, Vsevolod Makeev, Ivan Kulakovskiy, Philipp Bucher
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2020-05-01
Serie:	Genome Biology
Soggetti:	PWM Transcription factor binding sites Benchmarking ChIP-seq HT-SELEX PBM
Accesso online:	http://link.springer.com/article/10.1186/s13059-020-01996-3
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