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Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

Thyroid cancer is common, yet the sequence of alterations that promote tumor formation are incompletely understood. Here, we describe a novel model of thyroid carcinoma in zebrafish that reveals temporal changes due to BRAFV600E. Through the use of real-time in vivo imaging, we observe disruption in...

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Principais autores: Viviana Anelli, Jacques A Villefranc, Sagar Chhangawala, Raul Martinez-McFaline, Eleonora Riva, Anvy Nguyen, Akanksha Verma, Rohan Bareja, Zhengming Chen, Theresa Scognamiglio, Olivier Elemento, Yariv Houvras
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2017-03-01
Serier:eLife
Fag:
protooncogenes
epithelial cells
gene expression
EMT
Online adgang:https://elifesciences.org/articles/20728
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