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Differential Effector Engagement by Oncogenic KRAS

Summary: KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase, and RalGDS families, but many additional direct and indirect effectors have been reported. We have assessed how these effectors contr...

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Автори: Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2018-02-01
Серія:Cell Reports
Предмети:
KRAS
RSK
RNAi screen
paralogs
redundancy
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2211124718300834
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