Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways.

Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis that the reactive oxygen species (ROS)-sensitive a...

詳細記述

書誌詳細

主要な著者:	Reynolds K Brobey, Dwight German, Patricia K Sonsalla, Prem Gurnani, Johanne Pastor, C-C Hsieh, John Papaconstantinou, Philip P Foster, Makoto Kuro-o, Kevin P Rosenblatt
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2015-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	https://doi.org/10.1371/journal.pone.0139914
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!