Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Summary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number. We show that these focal deletions occur in the context of cyclin E1 amplification in breast, ovarian, and endometrial cancers, and serve to d...

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Autors principals:	Jeremiah Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Veronica Rendo
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-04-01
Col·lecció:	Cell Genomics
Matèries:	structural variants gene amplification BRD4 ovarian cancer breast cancer gene isoforms
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666979X25000710
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