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Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Summary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number. We show that these focal deletions occur in the context of cyclin E1 amplification in breast, ovarian, and endometrial cancers, and serve to d...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jeremiah Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Veronica Rendo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-04-01
Schriftenreihe:Cell Genomics
Schlagworte:
structural variants
gene amplification
BRD4
ovarian cancer
breast cancer
gene isoforms
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2666979X25000710
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