Click Chemistry and Multicomponent Reaction for Linker Diversification of Zinc Dipicolylamine-Based Drug Conjugates

An efficient Ugi multicomponent reaction with strain promoted azide-alkyne cycloaddition protocol has been utilized in concert or independently to prepare a small family of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. With sequential click chemistry coupling between the cytotoxi...

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Үндсэн зохиолчид:	Ching-Hua Tsai, Tai-Yu Chiu, Chiung-Tong Chen, Chia-Yu Hsu, Ya-Ru Tsai, Teng-Kuang Yeh, Kuan-Hsun Huang, Lun Kelvin Tsou
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2022-02-01
Цуврал:	Frontiers in Chemistry
Нөхцлүүд:	zinc dipicolylamine small-molecule drug conjugates phosphatidylserine tumor microenvironment click chemistry
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fchem.2021.822587/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!