BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

Zinc(II)-dipicolylamine (Zn-DPA) has been shown to specifically identify and bind to phosphatidylserine (PS), which exists in bulk in the tumor microenvironment. BPRDP056, a Zn-DPA-SN38 conjugate was designed to provide PS-targeted drug delivery of a cytotoxic SN38 to the tumor microenvironment, the...

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Hlavní autoři:	Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Chia-Yu Hsu, Teng-Kuang Yeh, Ching-Ping Chen, Chen-Lung Huang, Chung-Yu Huang, Min-Hsien Wang, Yu-Chen Huang, Hsuan-Hui Ho, Yu-Sheng Chao, Joe C. Shih, Lun K. Tsou, Chiung-Tong Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-01-01
Edice:	Translational Oncology
Témata:	BPRDP056 Dipicolylamine Phosphatidylserine targeting Drug conjugate Drug delivery
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1936523320303892
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