क्यूआर कोड

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.

में बचाया:
मुख्य लेखकों: Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P. Oude Elferink, Anastassis Perrakis
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Portfolio 2016-04-01
श्रृंखला:Nature Communications
ऑनलाइन पहुंच:https://doi.org/10.1038/ncomms11248
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