Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Summary: Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and T cell motility via LPAR2, yet its actions in the tumor immune microen...

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Detalhes bibliográficos

Principais autores:	Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Àvila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Koster, Fernando Salgado-Polo, Sander de Kivit, Telma Lança, Antonio Mazzocca, Zoë Johnson, John Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
coleção:	Cell Reports
Assuntos:	lysophosphatidic acid autotaxin chemorepulsion T cells G protein-coupled receptors tumor microenvironment
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124721014959
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