Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bradycardia to be due to microRNA (miR)-mediated tran...

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Detalhes bibliográficos

Principais autores:	Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-01-01
coleção:	Frontiers in Physiology
Assuntos:	G-protein-gated inwardly rectifying potassium 4 (Girk4) hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channel bradycardia sinoatrial node endurance athletes
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphys.2020.519382/full
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