The Metabolic Chemical Reporter Ac46AzGal Could Incorporate Intracellular Protein Modification in the Form of UDP-6AzGlc Mediated by OGT and Enzymes in the Leloir Pathway

Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent manner. It is noted that a vast majority of th...

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Detalhes bibliográficos

Principais autores:	Jiajia Wang, Biao Dou, Lu Zheng, Wei Cao, Peiyu Dong, Yingyi Chen, Xueke Zeng, Yinhang Wen, Wenxuan Pan, Jing Ma, Jingying Chen, Xia Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-10-01
coleção:	Frontiers in Chemistry
Assuntos:	OGT/OGA Leloir pathway GALE GALT Ac46AzGalactose metabolic chemical reporter
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fchem.2021.708306/full
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