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Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β

Abstract Transforming growth factor β (TGF-β) is implicated in both mesothelial-to-mesenchymal transition (MMT) and cellular senescence of human peritoneal mesothelial cells (HPMCs). We previously showed that senescent HPMCs could spontaneously acquire some phenotypic features of MMT, which in young...

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Kaydedildi:
Asıl Yazarlar: Edyta Kawka, Rebecca Herzog, Marcin Ruciński, Agnieszka Malińska, Markus Unterwurzacher, Juan Manuel Sacnun, Anja Wagner, Katarzyna Kowalska, Karol Jopek, Agata Kucz-Chrostowska, Klaus Kratochwill, Janusz Witowski
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2024-06-01
Seri Bilgileri:Scientific Reports
Konular:
Mesothelial cells
Mesothelial-to-mesenchymal transition
Cellular senescence
TGF-β
Online Erişim:https://doi.org/10.1038/s41598-024-63250-1
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