Generation of functional mesothelial cells from human iPSCs that restore peritoneal integrity in experimental peritoneal injury

Abstract Background Long-term peritoneal injury results in loss of mesothelial integrity and impaired ultrafiltration, limiting the durability of peritoneal dialysis. Because primary human peritoneal mesothelial cells (PMCs) are difficult to obtain and expand, regenerative strategies for restoring p...

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Autori principali:	Tadashi Kato, Mayu Yamashita, Masahiro Yasuda, Yutaro Ando, Ryusuke Nakatsuka, Yasumasa Shirouzu, Tatsuya Fujioka, Masayuki Tsukasaki, Fumiyuki Hattori, Yoshihiro Taniyama, Hiroaki Ogata, Akiko Sakashita, Hirokazu Honda, Hirofumi Hitomi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-04-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Induced pluripotent stem cells Peritoneal mesothelial cells Permeability Wound healing Peritoneal dialysis
Accesso online:	https://doi.org/10.1186/s13287-026-05037-x
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