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Management of diarrhoea in patients with stable ulcerative colitis with low FODMAP diet, amitriptyline, ondansetron or loperamide: the MODULATE RCT

Background Many patients with ulcerative colitis report ongoing diarrhoea even when their disease is stable and in remission. Design MODULATE was a pragmatic, multicentre, seamless, adaptive, phase 2/3 open-label, parallel-group, multiarm multistage randomised controlled trial. Setting and participa...

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Kaydedildi:
Asıl Yazarlar: Lauren A Moreau, Alexander Charles Ford, Matthew James Brookes, Sandra Graca, Elspeth Guthrie, Suzanne Hartley, Lesley Houghton, Karen Kemp, Nicholas A Kennedy, Yvonne McKenzie, Delia Muir, Pei Loo Ow, Christopher Probert, Emma Pryde, Christopher Taylor, Thomas A Willis, Alexandra Wright-Hughes, Amanda J Farrin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: NIHR Journals Library 2025-03-01
Seri Bilgileri:Health Technology Assessment
Konular:
ulcerative colitis
randomised controlled trial
multiarm multistage
platform trial
decentralised trial
Online Erişim:https://doi.org/10.3310/GHFE4871
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