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Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network

Neural circuits undergo massive refinements during postnatal development. In the developing cerebellum, the climbing fiber (CF) to Purkinje cell (PC) network is drastically reshaped by eliminating early-formed redundant CF to PC synapses. To investigate the impact of CF network refinement on PC popu...

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Principais autores: Jean-Marc Good, Michael Mahoney, Taisuke Miyazaki, Kenji F. Tanaka, Kenji Sakimura, Masahiko Watanabe, Kazuo Kitamura, Masanobu Kano
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-11-01
Serier:Cell Reports
Fag:
cerebellum
Purkinje cell
climbing fiber
postnatal development
in vivo calcium imaging
2-photon microscopy
population activity
synapse elimination
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124717315814
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