Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson's disease

Diagnosing early stage Parkinson's disease (PD) is still a clinical challenge. Previous studies using iron, neuromelanin (NM) or the Nigrosome-1 (N1) sign in the substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adopted c...

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Detalhes bibliográficos

Principais autores:	Naying He, Kiarash Ghassaban, Pei Huang, Mojtaba Jokar, Ying Wang, Zenghui Cheng, Zhijia Jin, Yan Li, Sean K. Sethi, Yixi He, Yongsheng Chen, Sara Gharabaghi, Shengdi Chen, Fuhua Yan, E. Mark Haacke
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-04-01
coleção:	NeuroImage
Assuntos:	Parkinson's disease Substantia nigra Neuromelanin Nigrosome-1 sign Magnetization transfer contrast Quantitative susceptibility mapping
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1053811921000872
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