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Effect of TAR hairpin stabilization on HIV-1 reverse transcription

ABSTRACT Reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires the first strand transfer that relies on a base-pairing interaction between the 3′ R sequence of the genomic RNA (gRNA) and the r sequence of the strong-stop DNA (ssDNA). The annealing reaction between...

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Gardado en:
Principais autores: Sandra Da Silva Amaral, Clémence Richetta, Lola Oualid, Nhat Quang Tu, Brigitte René, Olivier Mauffret, Olivier Delelis, Philippe Fossé
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2026-05-01
Series:Journal of Virology
Assuntos:
HIV-1
reverse transcription
TAR
strand transfer
nucleocapsid protein
structure
Acceso en liña:https://journals.asm.org/doi/10.1128/jvi.01840-25
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