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Whole-Body Physiologically Based Pharmacokinetic–Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

<b>Introduction/aim:</b> N-acetylgalactoseamine-conjugated small interfering RNAs (GalNAc-siRNAs) are an emerging class of drugs possessing an extensive clinical potential because of their high target specificity to the asialoglycoprotein receptor (ASGPR) in hepatocytes. Overall, GalNAc-sRNAs are we...

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Principais autores: Emilie Langeskov Salim, Kim Kristensen, Girish Chopda, Erik Sjögren
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Pharmaceutics
Fag:
GalNAc-siRNA
physiologically based pharmacokinetic modeling
PK-Sim
species translation
Online adgang:https://www.mdpi.com/1999-4923/17/9/1154
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