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MDM2 Antagonists Counteract Drug-Induced DNA Damage

Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and patient-derived xenografts. Among the tested...

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Main Authors: Anna E. Vilgelm, Priscilla Cobb, Kiran Malikayil, David Flaherty, C. Andrew Johnson, Dayanidhi Raman, Nabil Saleh, Brian Higgins, Brandon A. Vara, Jeffrey N. Johnston, Douglas B. Johnson, Mark C. Kelley, Sheau-Chiann Chen, Gregory D. Ayers, Ann Richmond
Format: Artigo
Language:Inglês
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
DNA damage
Replication stress
Mitotic inhibitor
MDM2 antagonist
Melanoma
Polyploidy
p21
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303699
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