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Structural basis of frizzled 7 activation and allosteric regulation

Abstract Frizzleds (ten paralogs: FZD1-10) belong to the class F of G protein-coupled receptors (GPCRs), which remains poorly understood despite its crucial role in multiple key biological functions including embryonic development, stem cell regulation, and homeostasis in the adult. FZD7, one of the...

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Bibliografische gegevens
Hoofdauteurs: Julien Bous, Julia Kinsolving, Lukas Grätz, Magdalena M. Scharf, Jan Hendrik Voss, Berkay Selcuk, Ogün Adebali, Gunnar Schulte
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2024-08-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-024-51664-4
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