BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. TFs largely function through enhancers, and enhancer deregulation is linked to cancer...

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मुख्य लेखकों:	Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Wiley 2026-05-01
श्रृंखला:	Advanced Science
विषय:	BCR::ABL1 CBP/P300 inhibitors enhancer reprogramming leukemia Ph+B‐ALL
ऑनलाइन पहुंच:	https://doi.org/10.1002/advs.202517231
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