BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. TFs largely function through enhancers, and enhancer deregulation is linked to cancer...

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Үндсэн зохиолчид:	Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2026-05-01
Цуврал:	Advanced Science
Нөхцлүүд:	BCR::ABL1 CBP/P300 inhibitors enhancer reprogramming leukemia Ph+B‐ALL
Онлайн хандалт:	https://doi.org/10.1002/advs.202517231
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!