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A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study

A sensitive and robust liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of nimbolide in mouse serum. Exemestane was used as the internal standard (IS). Here, we employed acetonitrile-based protein precipitation (PPT) for serum sample...

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Autori principali: Lingzhi Wang, Do-Dang Khoa Phan, Nicholas Syn, Xiaoqiang Xiang, Hongyan Song, Win Lwin Thuya, Shili Yang, Andrea Li-Ann Wong, Alan Prem Kumar, Wei Peng Yong, Gautam Sethi, Paul Chi-Lui Ho, Boon Cher Goh
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2018-08-01
Serie:Pharmaceutics
Soggetti:
nimbolide
LC-MS/MS
mouse
serum
pharmacokinetics
Accesso online:http://www.mdpi.com/1999-4923/10/3/123
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