A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study

A sensitive and robust liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of nimbolide in mouse serum. Exemestane was used as the internal standard (IS). Here, we employed acetonitrile-based protein precipitation (PPT) for serum sample...

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Bibliografische Detailangaben

Hauptverfasser:	Lingzhi Wang, Do-Dang Khoa Phan, Nicholas Syn, Xiaoqiang Xiang, Hongyan Song, Win Lwin Thuya, Shili Yang, Andrea Li-Ann Wong, Alan Prem Kumar, Wei Peng Yong, Gautam Sethi, Paul Chi-Lui Ho, Boon Cher Goh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2018-08-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	nimbolide LC-MS/MS mouse serum pharmacokinetics
Online-Zugang:	http://www.mdpi.com/1999-4923/10/3/123
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