γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

Abstract Background Amyloid-β peptide (Aβ) species of 42 or 43 amino acids in length (Aβ42/43) trigger Alzheimer´s disease (AD) and are produced in abnormal amounts by mutants of the γ-secretase subunit presenilin-1 (PS1), which represent the primary cause of familial AD (FAD). Lowering these peptid...

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Autores principales:	Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-02-01
Colección:	Alzheimer’s Research & Therapy
Materias:	Alzheimer’s disease γ-Secretase modulator Aβ Presenilin Familial Alzheimer’s disease
Acceso en línea:	https://doi.org/10.1186/s13195-025-01680-3
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