Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartrate-resistant acid phosphatase (TRAP, Acp5), a key...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Dilara Yılmaz, Francisco C. Marques, Yannick Fischer, Sandra Zimmermann, Gaonhae Hwang, Penny R. Atkins, Neashan Mathavan, Amit Singh, Pedro P.C. de Souza, Gisela A. Kuhn, Esther Wehrle, Ralph Müller
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2024-06-01
سلاسل:	Heliyon
الموضوعات:	Mechanosensitivity CRISPR/Cas9 mediated reporter mice Fluorescent osteoclasts and osteoblasts TRAP deficiency Trabecular bone remodeling Micro-computed tomography
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2405844024089801
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!