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Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartrate-resistant acid phosphatase (TRAP, Acp5), a key...

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Hoofdauteurs: Dilara Yılmaz, Francisco C. Marques, Yannick Fischer, Sandra Zimmermann, Gaonhae Hwang, Penny R. Atkins, Neashan Mathavan, Amit Singh, Pedro P.C. de Souza, Gisela A. Kuhn, Esther Wehrle, Ralph Müller
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2024-06-01
Reeks:Heliyon
Onderwerpen:
Mechanosensitivity
CRISPR/Cas9 mediated reporter mice
Fluorescent osteoclasts and osteoblasts
TRAP deficiency
Trabecular bone remodeling
Micro-computed tomography
Online toegang:http://www.sciencedirect.com/science/article/pii/S2405844024089801
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