Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway

Background/aim: Diabetes mellitus (DM) patients are at increased risk of cognitive impairment. The precise mechanisms underlying the association between DM and cognitive impairment remain unclear. Spleen tyrosine kinase (SYK), a crucial regulator of signal transduction, has been implicated in microg...

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Detalles Bibliográficos

Principais autores:	Chenglong Zhou, Jun Li, Xiaochu Wu, Fei Liu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-12-01
Series:	Experimental Gerontology
Assuntos:	Cognitive impairment Diabetes mellitus (DM) Spleen tyrosine kinase (SYK) Pyroptosis
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S0531556524002729
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