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Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway

Background/aim: Diabetes mellitus (DM) patients are at increased risk of cognitive impairment. The precise mechanisms underlying the association between DM and cognitive impairment remain unclear. Spleen tyrosine kinase (SYK), a crucial regulator of signal transduction, has been implicated in microg...

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Principais autores: Chenglong Zhou, Jun Li, Xiaochu Wu, Fei Liu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-12-01
Serier:Experimental Gerontology
Fag:
Cognitive impairment
Diabetes mellitus (DM)
Spleen tyrosine kinase (SYK)
Pyroptosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S0531556524002729
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