Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer

Abstract Prostate cancer is a highly heterogeneous disease, driven by genomic and transcriptional changes that impact disease progression and metastatic potential. The interplay between clonal evolution, transcriptional plasticity, and tumour microenvironment is, however, poorly understood. Here, we...

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Autors principals:	Migle Mikutenaite, Evdoxia Karadoulama, Francesco Favero, Alessio Locallo, Francisco German Rodriguez Gonzalez, Daria Kiriy, Tina Keshavarzian, Kira Furlano, Markus Graefen, Robert G. Bristow, Clarissa Gerhäuser, Christoph Plass, Guido Sauter, Ronald Simon, Mathieu Lupien, Sarah Minner, Thorsten Schlomm, Joachim Weischenfeldt
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-66704-w
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