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Defective pgsA contributes to increased membrane fluidity and cell wall thickening in Staphylococcus aureus with high-level daptomycin resistance

ABSTRACT Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of resistance is often attributable to mutations dire...

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Päätekijät: Christian D. Freeman, Tayte Hansen, Ramona Urbauer, Brian J. Wilkinson, Vineet K. Singh, Kelly M. Hines
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2024-06-01
Sarja:mSphere
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Linkit:https://journals.asm.org/doi/10.1128/msphere.00115-24
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