Interference of Sulphonate Buffering Agents with <i>E. coli</i> Hypoxanthine-Guanine Phosphoribosyltransferase Active Site Functioning: A Crystallographic and Enzymological Study

The investigation of the structure–function relationship in hypoxanthine-guanine phosphoribosyltransferases (HGPRT) is a direction that is relevant for the development of drugs and approaches of enzymatic synthesis of modified nucleosides and nucleotides. This research paper is dedicated to the inve...

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Principais autores:	Evgeniy A. Zayats, Yulia A. Abramchik, Maria A. Kostromina, Vladimir I. Timofeev, Mikhail B. Shevtsov, Alexey V. Mishin, Ilya V. Fateev, Andrey A. Karanov, Alexandra R. Sharafutdinova, Aleksandra O. Arnautova, Irina D. Konstantinova, Valentin I. Borshchevskiy, Roman S. Esipov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-10-01
coleção:	Crystals
Assuntos:	hypoxanthine-guanine phosphoribosyltransferase HGPRT HEPES biomacromolecule–ligand interaction enzyme structure structure–function relationship
Acesso em linha:	https://www.mdpi.com/2073-4352/15/10/874
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