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Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development

Abstract While the accessibility of enhancers is dynamically regulated during development, promoters tend to be constitutively accessible and poised for activation by paused Pol II. By studying Lola-I, a Drosophila zinc finger transcription factor, we show here that the promoter state can also be su...

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Autors principals: Vivekanandan Ramalingam, Xinyang Yu, Brian D. Slaughter, Jay R. Unruh, Kaelan J. Brennan, Anastasiia Onyshchenko, Jeffrey J. Lange, Malini Natarajan, Michael Buck, Julia Zeitlinger
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2023-09-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-023-41408-1
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