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Self-assembly of the bZIP transcription factor ΔFosB

ΔFosB is a highly stable transcription factor that accumulates in specific brain regions upon chronic exposure to drugs of abuse, stress, or seizures, and mediates lasting behavioral responses. ΔFosB reportedly heterodimerizes with JunD forming a canonical bZIP leucine zipper coiled coil that clamps...

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Guardat en:
Autors principals: Zhou Yin, Harikanth Venkannagari, Haley Lynch, Galina Aglyamova, Mukund Bhandari, Mischa Machius, Eric J. Nestler, Alfred J. Robison, Gabby Rudenko
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020-01-01
Col·lecció:Current Research in Structural Biology
Matèries:
ΔFosB
Activator protein-1 (AP-1)
Transcription factor
Basic leucine zipper
Protein accumulation
Neurological disorders
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2665928X19300054
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