ΔFosB is part of a homeostatic mechanism that protects the epileptic brain from further deterioration

Activity induced transcription factor ΔFosB plays a key role in different CNS disorders including epilepsy, Alzheimer’s disease, and addiction. Recent findings suggest that ΔFosB drives cognitive deficits in epilepsy and together with the emergence of small molecule inhibitors of ΔFosB activity make...

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Detalhes bibliográficos

Principais autores:	Jerome Clasadonte, Tania Deprez, Gabriel S. Stephens, Georges Mairet-Coello, Pierre-Yves Cortin, Maxime Boutier, Aurore Frey, Jeannie Chin, Marek Rajman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-01-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	ΔFosB granule cell dispersion neuroinflammation AAV-shRNA-ΔFosB mossy fibers homeostatic mechanism
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1324922/full
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