Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice

IntroductionLow back pain affects around 619 million people globally and is the most prevalent musculoskeletal condition worldwide. Low back pain is often difficult to treat with traditional drug combinations, and opioids are prescribed for up to 60% of patients with debilitating low back pain. This...

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Autori principali:	Vaskar Das, Isabella Milejczyk, Michael B. Basovich, Mario Moric, Jay Kaila, Craig J. Thomas, Asokumar Buvanendran, Robert J. McCarthy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-06-01
Serie:	Frontiers in Pain Research
Soggetti:	(2R, 6R)-hydroxynorketamine lumbar disk puncture musculoskeletal pain allodynia non-opioid analgesic glutamate receptor ionotropic (GluA1
Accesso online:	https://www.frontiersin.org/articles/10.3389/fpain.2025.1574474/full
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