Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice

IntroductionLow back pain affects around 619 million people globally and is the most prevalent musculoskeletal condition worldwide. Low back pain is often difficult to treat with traditional drug combinations, and opioids are prescribed for up to 60% of patients with debilitating low back pain. This...

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Автори:	Vaskar Das, Isabella Milejczyk, Michael B. Basovich, Mario Moric, Jay Kaila, Craig J. Thomas, Asokumar Buvanendran, Robert J. McCarthy
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2025-06-01
Серія:	Frontiers in Pain Research
Предмети:	(2R, 6R)-hydroxynorketamine lumbar disk puncture musculoskeletal pain allodynia non-opioid analgesic glutamate receptor ionotropic (GluA1
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fpain.2025.1574474/full
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